Find a Clinical Trial: Part One of Two
The NCI Clinical Trials Search Form (www.cancer.gov allows you to search a list of more than 8000 clinical trials now accepting participants, as well as a longer list of trials no longer recruiting. This video is Part One: How to use the search form to find cancer clinical trials that you or a loved one might be eligible to join. For additional guidance, see “Help Using the NCI Clinical Trials Search Form” (www.cancer.gov
Video Rating: 0 / 5
JVZoo Product Feed
Clinical implications of the biomarker analysis: TORCH trial – European Lung Cancer Conference 2012
Dr Mok highlights the strong value of EGFR mutation status when selecting the most effective treatment sequence in advanced NSCLC Abstract 163O Biomarkers of TORCH Trial on First-line Erlotinib Followed by Second-line Chemotherapy in Advanced Non-Small Cell Lung Cancer Patients MS Tsao1, C. Gallo2, M. Saieg1, GDC Santos1, V. Gebbia3, F. Perrone2, C. Butts4, F. Ciardiello2, R. Feld5, C. Gridelli6 1Toronto/CA, 2Napoli/IT, 3Palermo/IT, 4Edmonton, AB/CA, 5Toronto, ON/CA, 6Avellino/IT
JVZoo Product Feed
Categories: Videos Tags: 2012, conference, clinical, european, cancer, implications, biomarker, lung, torch, analysis
Dr. West Explains the Pemetrexed Clinical Trial
H. Jack West, MD, medical director of the Thoracic Oncology Program at the Swedish Cancer Institute in Seattle, Washington, describes progression free survival (PFS) for patients with advanced nonsquamous non–small cell lung cancer (NSCLC) in the PARAMOUNT phase III trial examining continuation maintenance therapy in two randomized arms; one receiving pemetrexed in addition to best supportive care and the other placebo and best supportive care.
Video Rating: 0 / 5
JVZoo Product Feed
Emphysema Clinical Trials – Franklin Square Hospital Center
Clinical trials are leading to new treatments and interventions… Visit: www.franklinsquare.org
Video Rating: 0 / 5
Christopher Drake explains how Buteyko’s Method reverses the symptoms of emphysema and COPD
Video Rating: 5 / 5
JVZoo Product Feed
Participating In Cancer Clinical Trials: Part 1 – What You Need To Know
Part 1 of a National Cancer Institute cancer clinical trials educational video created for people who are considering participation in a trial. The video explains and answers common questions about the types of clinical trials, how they are conducted, and factors to think about when deciding whether or not to participate in a trial. The video also features actual patients who share their reasons and decisions about participating in cancer clinical trials. View Part 2 of this video: www.youtube.com To order the entire Understanding Cancer Clinical Trials DVD and other free clinical trial educational materials, call NCI’s Cancer Information Service at 1-800-4-CANCER (1-800-422-6237) or visit www.cancer.gov . You can find additional information about clinical trials online at www.cancer.gov NCI’s Cancer Information Service is also available to answer other questions you may have: 1-800-422-6237 For Copyright Notice and Restrictions please visit our Web site at www.cancer.gov
Video Rating: 5 / 5
JVZoo Product Feed
Dr Paz-Ares Discusses Pemetrexed Clinical Trial
Luis Paz-Ares, MD, PhD from Seville University Hospital in Spain Discusses the Pemetrexed Advanced Nonsquamous Non–Small Cell Lung Cancer Clinical Trial
Video Rating: 0 / 5
JVZoo Product Feed
GRACEcast-084_Lung-Cancer_ALK Inhibition: Science and Early Clinical Experience by Dr. Ben Solomon
cancergrace.org Dr. Ben Solomon of Peter MacCallum Cancer Centre in Melbourne Australia reviews ALK Inhibition from mechanism of action to activity and side effect profile of crizotinib, newly approved for patients with ALK-positive advanced non-small cell lung cancer.
Video Rating: 5 / 5
JVZoo Product Feed
Categories: Videos Tags: experience, gracecast084_lungcancer_alk, inhibition, science, early, clinical, solomon
Are there any clinical trials being done that could type and screen cancer samples to specific chemotherapies?
Question by Dks97: Are there any clinical trials being done that could type and screen cancer samples to specific chemotherapies?
Sort of like how blood is typed and screened. If a patient knew how their cells reacted to a specific regimen, it would save time going down a long list of chemotherapies. If a sample is taken and tested before chemo is scheduled to start, a patient could go right to that specific drug match and benefit. My mother has breast cancer and is on her 3rd drug combo. We keep going down a list of compatible drugs for her cancer type not knowing which will be a good long term match for her.
Best answer:
Answer by bmac
Here is the clinical trials site.
http://www.clinicaltrials.gov/
What do you think? Answer below!
JVZoo Product Feed
Categories: News Tags: samples, being, specific, could, done, screen, trials, clinical, there, chemotherapies
Dr. Edwin Silverman talks about COPDGene and importance of clinical research participation
In this video—presented by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health—NHLBI grantee Dr. Edwin Silverman of Brigham and Women’s Hospital in Boston talks about COPD Gene, which he runs with Dr. James Crapo of National Jewish Health in Denver, and about the importance of participation in clinical studies. COPD Gene is a study of more than 10000 volunteers across the country who are undergoing genetic assessment, state-of-the-art CAT scan imaging, breathing tests and other measurements in order to better understand why some people get COPD (chronic obstructive pulmonary disease) and others don’t. The goal is to identify the genes that play a role in the development of COPD and to ultimately improve the prediction, diagnosis, and treatment of the disease. “This research would not have been possible without the incredible support from the general population,” said Dr. Silverman. “If we hadn’t had enthusiastic support from our volunteers who gave up their own time to come in, get a CAT scan, go through an extensive array of tests with breathing tests and walk tests and a long list of questionnaires, if they hadn’t been willing to do that, we just couldn’t do the work. “So I think that people need to understand that medical research isn’t something that happens out there by other people. If they want new medical discoveries, they should really consider getting involved. They should consider being part of clinical trials, consider …
Video Rating: 5 / 5
JVZoo Product Feed
Categories: Videos Tags: edwin, importance, participation, silverman, copdgene, research, clinical, about, talks
Advocacy in Action: Role of Global Advocate Community in Research & Clinical Trials
This discussion is led by Prof. David Kerr (President of ESMO), Diane Blum (CEO Lymphoma Research Foundation) Regina Vidaver (Exec. Dir. of the Nat’l Lung Cancer Partnership) and Selma Schimmel (Founder & CEO Vital Options International. Featuring Cancer Advocates: Arin Assero (International Myeloma Foundation), Andrea Evans (Y-Me National Breast Cancer Foundation) and Kim Ryan (Fight Colorectal Cancer).
Video Rating: 0 / 5
JVZoo Product Feed
Categories: Videos Tags: clinical, community, global, role, advocate, research, advocacy, action, trials
Young TIL Clinical Trial – Immunotherapy Program Milwaukee
VISIT WWW.THEIDEARAISER.COM FOR MORE INFORMATION Milwaukee is one of a few places in the world offering the Young TIL Clinical Trial. This treatment is providing amazing hope to patients suffering from melanoma, a form of cancer that kills thousands of people annually. Further, the research being done right here in Milwaukee holds exciting potential for other types of cancers. A patient suffering from stage four melanoma, who is otherwise fairly healthy but hasn’t responded to first level treatments including Interleukin 2, is assessed through a prescreening process to participate in the FDA cleared, Young TIL clinical research trial. In a nutshell, the Young TIL cell (or tumor infiltrating lymphocytes) are an army created from the patient’s own immune cells…those cells that can kill the cancer. this is a good treatment, it’s a new era, it’s a new world, it’s custom designed, it’s personalized, it’s your cells doing the job. And it may open the door in the same way that radiation therapy did and the same way chemotherapy did, and I’m convinced that this type of interesting and complex manipulation of the immune system is going to blow it open even more so.” — Dr. John Hanson Patient Testimonial “This is about a revolutionary treatment that can help cancer patients.” “It is an experiment, it is a trial, but guess what. It’s workin. And it’s workin incredibly well for patients like myself and others” — Jeff, Patient
JVZoo Product Feed
Why are clinical trials important for early detection research?
Simone Marticke, PhD, Canary Foundation Scientific Program Manager, explains the purpose of clinical trials and how they impact early cancer detection research. To learn more about the Canary Center at Stanford, visit: www.canaryfoundation.org/canary-center
Video Rating: 0 / 5
JVZoo Product Feed
Dr. Reckamp on Current Heat Shock Protein Clinical Trials
Karen Reckamp, MD, MS, assistant professor, Department of Medical Oncology & Therapeutics Research, City of Hope, Duarte, California, describes the various clinical studies currently underway examining the use of heat shock proteins. Clinical trials are currently looking specifically at ALK translocated, crizotinib resistance, and patient that have not yet received crizotinib. Further examination is being completed into heat shock proteins in combination with docetaxel and other targets and biomarkers that specify which patients will have the most benefit.
Video Rating: 0 / 5
JVZoo Product Feed
Management of IPF: Recent Advances in Prognosis, Co-Morbidities and Clinical Trials Part 1 of 10
Presentation by Imre Noth, MD, Associate Professor of Medicine at the University of Chicago for the 2009 Pulmonary Fibrosis Symposium at St. Mary’s Medical Center in Evansville, Indiana. Part 1 of 10.
Video Rating: 0 / 5
Savannah Aulger will never have snapshots with her father on her first birthday, on Christmas or at a school event. The only picture she will ever have of them is the one as sweet as it is heartbreaking. Hooked up to an oxygen mask at the hospital, the man she would call dad cradled her in his arms for 45 minutes. He sobbed. He smiled. And there was no doubt that he loved her. “He would talk to my stomach when I was pregnant,” Diane Aulger said of her husband. “He was so excited for her.” The next day, Mark Aulger slipped into a coma. The Aulger family of The Colony, Texas, had a lot to rejoice about in the weeks before Savannah’s Jan. 18 birth, which was induced two weeks early so her father could hold her. A home movie on Christmas showed a pregnant Diane Aulger, 31, handing out gifts to their four children, the oldest of whom is 15. Mark, 52, who had just received the news that he had beaten cancer, played the guitar, providing a soundtrack for the Christmas morning festivities. On Jan. 3, life threw a curveball. ABC News Diane Aulger induced labor so her dying… View Full Size Homeless Man’s Dying Wish: Dog Reunion Watch Video Dying Man Gets Wish for Citizenship Watch Video Dying Boy Meets Santa Watch Video Mark Aulger was admitted to the hospital, unable to breathe. Doctors told him that eight months of chemotherapy had ravaged his lungs and diagnosed him with pulmonary fibrosis. “We thought he could get on steroid treatment and oxygen and live for years,” Diane …
JVZoo Product Feed
Categories: Videos Tags: comorbidities, management, recent, part, prognosis, clinical, advances, trials
Gastric Emphysema: Causes, Clinical Implications, and CT Findings.
Gastric Emphysema: Causes, Clinical Implications, and CT Findings.
Video Rating: 5 / 5
JVZoo Product Feed
Lung Cancer Blood Test – EarlyCDT-Lung Clinical Staff Testimonials
Watch as various hospital and clinical staff members discuss using the EarlyCDT-Lung blood test for early lung cancer detection in their offices. See what they think about EarlyCDT technology, the availability of the test, and how useful it has been in their practices For more information, visit hellohaveyouheard.com?utm_campaign=Clinical-Staff-Testimonials&utm_source=YouTube Additional information on EarlyCDT-Lung, lung cancer symptoms, risk assessment and other related topics, as well as additional physician testimonials can be found at HelloHaveYouHeard.com.
Video Rating: 5 / 5
JVZoo Product Feed
Categories: Videos Tags: clinical, earlycdtlung, test, lung, staff, cancer, blood, testimonials
American College of Physicians: New Clinical Recommendations for Diagnosing and Treating COPD
The American College of Physicians (ACP), American College of Chest Physicians (ACCP), American Thoracic Society (ATS), and European Respiratory Society (ERS) today released a joint clinical practice guideline on diagnosing and treating stable chronic obstructive pulmonary disease (COPD) in Annals of Internal Medicine, ACP’s flagship journal. ACP convened the four organizations, which represent more than 170000 physicians from around the world, to develop the joint guideline. “This clinical practice guideline aims to help clinicians to diagnose and manage stable COPD, prevent and treat exacerbations, reduce hospitalizations and deaths, and improve the quality of life of patients with COPD,” said lead author Amir Qaseem, MD, FACP, PhD, Director of Clinical Policy, American College of Physicians. “It is important for patients with COPD to stop smoking and for physicians to help their patients to quit smoking.” COPD occurs predominantly in cigarette smokers. COPD symptoms include chronic cough, wheezing, shortness of breath, or significant activity limitation.
Lisa Lavange, biostatistics professor and Collaborative Studies Coordinating Center director, describes research involving the US Hispanic population and chronic obstructive pulmonary disease (COPD).
Video Rating: 0 / 5
JVZoo Product Feed
Categories: Videos Tags: college, copd, recommendations, diagnosing, physicians, clinical, american, treating
No More Hand-Me-Down Research (Children and Clinical Studies)
Children have often had to accept medicines and treatments based on what is known to work in adults. The National Heart, Lung, and Blood Institute is eager to improve the evidence to ensure the safety and efficacy of therapies for all children. We have provided this video to help families and investigators make wise decisions. Learn more at www.nhlbi.nih.gov This video was made possible by grants from the NHLBI (part of the National Institutes of Health), the National Marfan Foundation, and the NIH’s National Center for Research Resources.
Video Rating: 1 / 5
a Know What to Do About the Flu On August 27, an expert panel discussed how pregnant women and new mothers can prepare for the H1NI flu. Email questions were answered by the panel during the broadcast. Guests: HHS Secretary Kathleen Sebelius Tina Chin, White House Council on Women Anne Schukat, CDC Cntr for Immunizat’n & Resp Diseases Tony Fauci, National Institutes of Health – NIAD Dr. Laura Riley, Mass General Hospital More info at www.flu.gov We allow comments according to our comment policy newmedia.hhs.gov
JVZoo Product Feed
Clinical Experience of Rapamycin Inhibitors in the Treatment of Other Solid Tumors
Clinical Experience of Rapamycin Inhibitors in the Treatment of Other Solid Tumors
Article by Cdkinhibitors
Subependymal giant-cell astrocytoma (SEGA) results from mutations in the TSC1 or TSC2 genes, whose products are major regulatory proteins linked to the activation of the mTOR pathway. A recent phase II trial of everolimus in children and adults with SEGAs showed significant reduction in tumor volume in a majority of the patients with decreased occurrence of seizures. Notably, the drug was well tolerated even with prolonged treatment, suggesting that it may be an attractive alternative to surgical resection in selective cases. On the contrary, a phase II trial with temsirolimus in patients with recurrent glioblastoma multiforme (GBM) did not show efficacy.
There has been also substantial interest towards the development of mTOR inhibitors for the treatment of sarcomas. Temsirolimus has failed to demonstrate meaningful activity as monotherapy in these tumors, as evidenced by a phase II trial in which PFS was only 2 months. Everolimus, on the contrary, may have synergistic activity with imatinib mesylate in gastrointestinal stromal tumors (GIST). Phase I/II data of this combination in patients who progressed with imatinib mesylate alone showed a modest improvement in progression-free survival (PFS). A phase II trial with ridaforolimus in 216 patients with advanced sarcoma was carried out. Patients enrolled included osteosarcoma, leiomyosarcoma, liposarcoma and other soft tissue sarcomas. In several cases stable disease was attained, with amedian survival of 40 weeks, and outcomes were similar between the four histologic subtypes.
Besides brain tumors and sarcomas, mTOR inhibition has been studied in various other solid tumors, including gastrointestinal, prostate, and head and neck cancers. The combination of bevacizumab and everolimus exhibited clinical activity in patients with metastatic colorectal cancer, despite previous progression on a bevacizumab-based regimen. There is also preliminary evidence from a study in patients with hepatocellular carcinoma suggesting that everolimus may be moderately active in stabilizing disease progression. Other trials combining mTOR inhibitors with sorafenib or bevacizumab in patients with hepatocellular carcinoma are ongoing. The combination of bicalutamide and everolimus appears to have promising antitumor activity and an acceptable toxicity profile in castrate-resistant prostate cancer, whereas various trials with rapalogs are being conducted for either the treatment of advanced prostate cancer or in the neo-adjuvant setting.
References
Adriaensen ME, et al. Eur J Neurol 2009; 16: 691-696. Krueger DA, et al. N Engl J Med 2010; 363: 1801-1811. Dumez H. J Clin Oncol 2008; 26: abstract 10519. Altomare I, et al. J Clin Oncol 2010; 28(15Suppl): abstract 3535. Chen L, et al. J Clin Oncol 2009; 27 (15Suppl): abstract 4587. Kelley RK, et al. J Clin Oncol 2011; 29: (4Suppl): abstract 296. Pan C, et al. J Clin Oncol 2010; 28 (15 Suppl): e15131. Phase Ib/II evaluation of RAD001 with docetaxel and bevacizumab in patients with metastatic androgen independent cancer (NCT00574769). http://www.clinicaltrials.gov. [Accessed in Spring 2011]
Related Posts
Clinical Experience of Rapamycin Inhibitors in the Treatment of Breast CancerPosts Related to Clinical Experience of Rapamycin Inhibitors in the Treatment of Other Solid Tumors
Clinical Experience of Rapamycin Inhibitors in the Treatment of Breast Cancer
Clinical trials have evaluated the efficacy of rapalogs with endocrine therapy as neoadjuvant treatment, as well as the role of rapalogs in the treatment of … Clinical Experience of Rapamycin Inhibitors in the Treatment of Lung Cancer and Pancreatic Neuroendocrine Tumors
There have been phase I and II clinical trials to assess the clinical efficacy of everolimus in lung cancer. A phase I study of everolimus … Clinical Experience of Rapamycin Inhibitors in the Treatment of Renal Cell Carcinoma
Both temsirolimus and everolimus have been approved for the treatment of advanced renal cell cancer (RCC). In a randomized control trial, temsirolimus was compared to …
About the Author
To meet customers’s needs and satisfaction, our purpose is to provide scientists world-wide an easy access to the most innovative life science reagents like PLX-4032, Vemurafenib, Zelboraf, Crizotinib, PF-2341066 and to help them make more significant discoveries.
JVZoo Product Feed
Categories: Articles Tags: inhibitors, rapamycin, solid, treatment, experience, clinical, tumors
