Posts tagged "Shows"

What type of cancer could you have if CT scan shows enlarged lymph nodes in pelvic area?

Question by FLAWDA::BABii: What type of cancer could you have if CT scan shows enlarged lymph nodes in pelvic area?
Any specific types?
I am scheduled for a PET scan this is why
I ask

Best answer:

Answer by Denisedds
Having enlarged lymph nodes does not mean you have cancer.
And if you did have cancer there are no specific types as most of them can involve any part of the body.

Know better? Leave your own answer in the comments!

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2 comments - What do you think?
Posted by John Hocking - 5/20/2012 at 3:30 am

Categories: News   Tags: nodes, type, scan, shows, could, area, cancer, enlarged, pelvic, lymph

what talk shows will sasha baron cohen aka bruno be on in the near future?

Question by misljol: what talk shows will sasha baron cohen aka bruno be on in the near future?
He is hilarous and I want to DVR his interviews, but I can’t seem to find a listing of when he’d be on (short of looking at EVERY show’s lineup!)

And if he’s recently been on anything else, let me know to look on Hulu!

Best answer:

Answer by [ * - * ]
Last night he was on the Tonight Show with Conan O’brien.

Sasha is so funny! :p

Add your own answer in the comments!

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1 comment - What do you think?
Posted by John Hocking - 4/21/2012 at 6:45 pm

Categories: News   Tags: shows, talk, near, baron, bruno, cohen, sasha, future

Q&A: An MRI shows a 1cm spot on my mom’s right lung.?

Question by : An MRI shows a 1cm spot on my mom’s right lung.?
My mom went in for an MRI on her lower abdemon and a 1cm spot was found on her lung. They are going to do a CT to see if there are other spots, she is 80 years old, never has smoked, what are the chances this is cancerous? Thank you for any helpful input.

Best answer:

Answer by melissa
A CT will give better imaging of her lungs but chances are if there weren’t more seen in the MRI they will be very small on the CT, if there at all. If its just the one spot that’s there chances are nothing will be done about it because it is so small. It would end up being a wait and see approach, if it is cancer at all. I hope everything turns out!

Give your answer to this question below!

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2 comments - What do you think?
Posted by John Hocking - 4/18/2012 at 9:30 am

Categories: News   Tags: shows, lung, mom's, spot, right

Arvada/Boulder Colorado Shows You: How To Remove Vinyl Flooring

www.denver-hardwood-flooring.com Remove old vinyl flooring with our easy-to-follow video and step-by-step instructions. All you need are a few simple tools to remove the vinyl flooring as well as the plywood underlayment and staples. For more information on this process go to: www.denver-hardwood-flooring.com About us: Alpine Flooring Inc is located in in the Denver/Boulder Colorado. We serve most areas including Arvada, Boulder, Broomfield and Lafayette in the north and Castle Pines, Highlands Ranch and Parker in the south. Please visit our web site for more information on hardwood installation, sanding, refinishing and repairs. www.denver-hardwood-flooring.com

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6 comments - What do you think?
Posted by John Hocking - 4/7/2012 at 5:00 pm

Categories: Videos   Tags: shows, vinyl, arvada/boulder, colorado, remove, flooring

What do you think Herman Cain was going for, with that ad, that shows his chief of staff, smoking?

lung cancer support
by MSVG

Question by : What do you think Herman Cain was going for, with that ad, that shows his chief of staff, smoking?
Was he trying to get funding from the tobacco lobby? Was he endorsing smoking?

Was he saying, “Hi, I’m Herman Cain, and I SUPPORT Lung cancer ? ” What?

BQ. Could he have looked any CREEPIER in that ad?

Best answer:

Answer by Homey Don’t Play Dat!
Cain has little money and knew the libbies would be outraged and falling all over themselves to show it for free… he’s playin’ yall.

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9 comments - What do you think?
Posted by John Hocking - 4/5/2012 at 6:15 pm

Categories: News   Tags: staff, think, shows, cain, chief, going, smoking, herman

My mother Chest X-ray shows consolidative lesion left hila. she also have blood with cough.plzzzzzz help?

lung lesion
by Pulmonary Pathology

Question by IMRAN S: My mother Chest X-ray shows consolidative lesion left hila. she also have blood with cough.plzzzzzz help?
Rest of the lungs are clear.
Heart size normal.
Costophrenic angles are clear.

Best answer:

Answer by beaches
With all due respect, what is it that you need to hear? Hopefully, your mom is being followed by a physician in order to have the lesion biopsied if appropriate and for the blood with her cough.

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Be the first to comment - What do you think?
Posted by John Hocking - 4/1/2012 at 3:15 am

Categories: News   Tags: shows, xray, cough.plzzzzzz, hila., blood, lesion, mother, also, chest, consolidative

Marijuana Study Shows No Lung Cancer Links.mov

Pulmonary specialist and Federal Government researcher from UCLA Geffen School of Medicine finds that marijuana does not cause lung cancer in his study on the effects of cannabis and the lungs. Results of this study are discussed for the first time. If you agree that cannabis should be legal, write a letter to your congressperson and tell them to legalize it! Cannabis was made illegal because the paper industry was split between the hemp and the wood pulp factions. The wood pulp people had more money and won, which caused a negative ripple effect in our society such as the loss of a valuable medicine. Since the prohibition of cannabis began the cancer rates have grown at an alarming rate. Cannabis is used for thousands of purposes and it’s loss of use has caused great hardship to everyone. It is time for truth to prevail and prohibition to stop.
Video Rating: 5 / 5

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1 comment - What do you think?
Posted by John Hocking - 3/13/2012 at 2:45 am

Categories: Videos   Tags: shows, study, cancer, links.mov, marijuana, lung

Cancer not shown on X Ray, but shows up on CT scan a week later?

Question by Ribbons: Cancer not shown on X Ray, but shows up on CT scan a week later?
A family member passed from ischemic intestine 6 months ago and I saw his medical records today. A chest x ray showed nothing, but less than a week later a ct scan showed 2 large masses and several smaller ones throughout the lungs. How is this possible? Also, can what’s shown on the CT scan be positively identified as malignancies without further testing?

Best answer:

Answer by me
CT scans can show more than an xray can.

Add your own answer in the comments!

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3 comments - What do you think?
Posted by John Hocking - 3/10/2012 at 12:30 pm

Categories: News   Tags: shows, week, cancer, later, shown, scan

AACR 2011: Combination therapy targeting MEK and PI3K pathways shows anti-tumour activity

Dr Johanna Bendell – Sarah Cannon Research Institute, Nashville, USA. The combination of two compounds that inhibit two of the most frequently mutated cancer pathways is showing promise in an ongoing Phase I trial. The research, presented by Dr Johanna Bendell, tests a combination of GDC-0973, which inhibits MEK1/2 and GDC-0941, which inhibits PI3K. The patients received a combination of different doses of GDC-0973 and GDC-0941; these drug combinations were well tolerated and only produced with mild side effects. Several patients demonstrated decreases in tumour size, including two patients with melanoma, one with prostate cancer and two with non-small cell lung cancer. It is hoped that these targeted treatments will eventually help clinicians treat cancers more effectively and will produce fewer adverse effects than current therapies.
Video Rating: 5 / 5

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Be the first to comment - What do you think?
Posted by John Hocking -  at 9:15 am

Categories: Videos   Tags: pathways, therapy, shows, targeting, activity, 2011, aacr, antitumour, pi3k, combination

Metastatic breast cancer spread to colon, been on chemo for 4 months and CT scan shows no changes?

metastatic lung cancer
by Pulmonary Pathology

Question by Yvonne: Metastatic breast cancer spread to colon, been on chemo for 4 months and CT scan shows no changes?
We found out my mom’s metastatic breast cancer most recently spread to her colon after a colonscopy in June. She’s been on more aggressive chemo since then and her most recent CT scan done (a couple weeks ago) shows no change at all.

It has also spread to her hip bone, lungs and liver, along with a second occurrence of breast cancer in between, and treatments for those areas showed great improvements. She’s been on chemo and Herceptin for 5+ years which has worked considerably well, she’s a 12 year survivor so far.

Is the colon a harder area to treat when it has spread there? She went from 3 hour treatments one week on/3 weeks off to 8 hour treatments for 3 weeks on/1 week off in addition to Herceptin, plus a new chemo pill she’s never had before. The good news is the spots haven’t gotten any bigger but her doctor is concerned there hasn’t been any progress at all after 4 months.

Any advice or personal experiences are greatly appreciated. Thank you.

P.S.–>Denise, I’m sure you will read this and like I said, I appreciate your answers so feel free to answer.

Best answer:

Answer by Memere RN/BA
I’m not Denise but I respect her expertise. However, as a nurse, I have seen patient with colon cancer have surgery and survive only they use a bag because the disease part of the colon is removed and instead of normal bowel movements, a bag is in place on the abdomen. I had to aunts that had this. One of my aunts had a reversal because all signs of the cancer was gone after treatment. Even though a bag is in place, chemo continues to get residual cancer cells. It sounds like your mom’s cancer has spread beyond the colon. All I can say is I pray she fells that special peace that passes all understanding. I pray she gets well. God bless.

Know better? Leave your own answer in the comments!

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1 comment - What do you think?
Posted by John Hocking - 3/7/2012 at 12:00 pm

Categories: News   Tags: metastatic, colon, spread, shows, cancer, scan, been, breast, changes, months.

Science shows Marihuana kills cancer cells

Original: www.youtube.com Also see “RUN FROM THE CURE: The Rick Simpson Story”. youtube.com
Video Rating: 4 / 5

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25 comments - What do you think?
Posted by John Hocking - 2/27/2012 at 10:00 pm

Categories: Videos   Tags: science, shows, cancer, cells, marihuana, kills

Q&A: cancer (if a x-ray shows something and a ct scan and die does also whats the chances its cancer?

lung cancer x ray
by Thirteen Of Clubs

Question by heavensendme: cancer (if a x-ray shows something and a ct scan and die does also whats the chances its cancer?
my husband had cancer 11 years ago hodgkins stage 4 he went to hosptial and they did a x-ray and seen something so they did a ct scan and die and still seen something in the top right lung he said something about 2 lumps and he dont know if his hodgkins came back or not. i have made his appointment but i am wondering since they sending us to a cancer center and by what they seen could it be something else the waiting is eating me up he is hoase he should have never made it 11 years ago they said but it wasnt lungs either

Best answer:

Answer by jess
firsty im really sorry to hear this! sounds like the doctor suspects somthing is wrong here thats y he sent u back 2 the cancer centre , you could make an appointment with your gp for this week and talk to him/her see if they can give u any indication as to what they have seen on the scan! i know its hard but try 2 stay calm!
i really hope everything is ok for you i really do!
i wish u all the luck inthe world and if it is his cancer has come back he can fight it again just like he did the first time he sounds so strong and is lucky to have you there with him!
all the best jess xx

What do you think? Answer below!

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5 comments - What do you think?
Posted by John Hocking - 2/18/2012 at 10:30 am

Categories: News   Tags: whats, xray, shows, also, cancer, chances, something, scan

Study Shows Doctors Less Likely to Give Chemotherapy after Surgery to Older Colon Cancer Patients

The World Health Organization lists colon cancer among the deadliest diseases. In 2004, some 639-thousand people around the world died from colon cancer. If caught in time, surgery and chemotherapy are effective treatments. But a new randomized trial finds that older cancer patients aren’t always offered another treatment option that might extend their lives. VOA’s Melinda Smith explains.
Video Rating: 5 / 5

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Be the first to comment - What do you think?
Posted by John Hocking - 2/13/2012 at 11:30 am

Categories: Videos   Tags: likely, study, cancer, surgery, less, patient's, colon, shows, after, chemotherapy

What does it mean when a chest x-ray shows a change in density in lower lobe of lung?

Question by motherofthree: What does it mean when a chest x-ray shows a change in density in lower lobe of lung?
the reason why my dad went to the doctor was because he has been coughing up blood for serveral months and had throat cancer last year and they originally thought it was dry air but now with the abnormal chest x-ray I wonder what that means??
He had to have a complete larengectomy last year. He was given no radiation after the surgery.

Best answer:

Answer by Sane
Sadly that is a big sign of fluids in the lung and is caused by cancer. Lost both parents in law to that and its nasty but mercifully fast.

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1 comment - What do you think?
Posted by John Hocking - 2/12/2012 at 8:30 am

Categories: News   Tags: xray, lower, shows, mean, change, chest, density, lung, lobe

Q&A: pet scan that shows something in the left lung.?

pet scan lung cancer
by wipeoutpdr

Question by : pet scan that shows something in the left lung.?
doctor wants second pet scan in 90 days.i had breast cancer with right breast removed,2003,why do you think he wants second scan.i i`m asking this for my mother.

Best answer:

Answer by random
A pet scan shows increase in metabolic activity in a particular place in the body. Cancer/ infections can light up as a spot on a pet scan. Your mother’s doctor is probably looking to make sure that either the spot in the lung disappeared (i.e. it was something noncancerous) or if it is still there or larger, they may opt to biopsy it (if it’s posssible to rule out cancer). Breast cancer can spread to the lungs that’s why her doctor is concerned. You should not stress out over this issue. There is still a chance that it could be just an artifact.

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2 comments - What do you think?
Posted by John Hocking - 1/17/2012 at 8:30 pm

Categories: News   Tags: shows, left, lung, something, scan

Did you know that new research shows that marijuana actually kills cancer cells… rather than creating them?

cancer wiki
by Mataparda

Question by Bill S: Did you know that new research shows that marijuana actually kills cancer cells… rather than creating them?
Did you know that marijuana kills cancer cells? It actually causes them to eat themselves in a process called “autophage”.

Also, instead of killing brain cells, studies show it actually promotes the growth of new brain cells?

http://www.newscientist.com/article/dn8155-marijuana-might-cause-new-cell-growth-in-the-brain.html

Example Cancer Studies:

THC (marijuana) helps cure cancer says Harvard study

http://www.sciencedaily.com/releases/2007/04/070417193338.htm

Marijuana Chemical May Fight Brain Cancer
Active Component In Marijuana Targets Aggressive Brain Cancer Cells, Study Says

http://www.webmd.com/cancer/brain-cancer/news/20090401/marijuana-chemical-may-fight-brain-cancer

Did you know the government knew about it in 1974?

http://www.alternet.org/story/9257/

Did you know that the cannabinoid receptor is the most prevalent cellular receptor in our brains?

http://en.wikipedia.org/wiki/Cannabinoid_receptor

This mystery began to unravel in 1964, when tetrahydrocannabinol, or THC, the main psychoactive chemical in cannabis was isolated and synthesized by Raphael Mechoulam and colleagues in Israel. Subsequently, in 1988, Allyn Howlett and colleagues discovered the cannabinoid receptor in the brain. This receptor called CB1was a precise match for the unique chemicals called cannabinoids found in the cannabis plant (phytocannabinoids). This initial discovery led to scientists hypothesizing that humans are “wired” for cannabis. The CB1receptors have been found in the brain in areas that control the coordination of movement, emotions, memory, reduction of pain, reward systems, and reproduction, yet are almost absent in the brain stem (which affects our vital functions such as breathing). It appears that cannabinoid receptors, which modulate other neurotransmitter function in a retrograde “on demand” fashion are present in far higher concentrations in the brain than any other receptor. While the CB1 receptors are primarily found in the central nervous system, a second type, CB2, discovered in 1993, are found primarily in the immune system, GI tract, liver, spleen, kidney, bones, heart, and peripheral nervous system. In fact, the CB2 receptor appears to be up-regulated whenever there is tissue pathology.

What do you think about this?

Did the government know?

What do you think about that?

Did you know that the government actually has the patent on medical marijuana… for use in fighting diseases such as cancer, Crohn’s disease, multiple sclerosis, Alzheimer’s disease and more?

And yet they repeatedly say that there is “no medical use” for marijuana.

Look it up. U.S. Patent #6630507

It’s like a MIRACLE DRUG because the endocannabinoid system in your body controls so much chemically… by stimulating this system, many positive effects can occur in many different organs of the body.

If you don’t believe me, check out the studies at www.pubmed.gov … just type “cannabinoids” and “cancer” in the search bar and you’ll see the results of the HUNDREDS of studies that show that the THC in marijuana actually kills cancer cells, both in human tissue cultures and in animals. But… they won’t let us do studies on humans because mj has been labeled the “devil’s weed”. HA!

But there is plenty of anecdotal evidence. (People who didn’t want to wait on the government to legalize medical marijuana to help with their illness. We’ve been waiting over 40 years, after all.) I have been in correspondence with the head of the biology dept at a major university in Colorado, and he’s knows people personally who have used super-concentrated cannabis oil to CURE their cancer.His own girlfriend got rid of her skin cancer completely applying cannabis oil topically. You can also find video diaries on the internet of people who have gotten rid of skin cancer using cannabis oil. Also video diaries of people who have had miraculous healing of 3rd degree burns. One video diary I found had an AIDS patient who was ingesting the oil and cut his T-cell count from over 800 to around 400 in just a few weeks.

Rick Simpson has cured hundreds of people over the last few years and has plenty of written and videoed testimony. Google “Run from the Cure”.

If you want to see the enormous number of medical conditions that marijuana is GOOD for, check this out…

http://forum.grasscity.com/medical-marijuana/436257-granny-storm-crows-list-july-2009-a.html

This is a video everyone should watch…

Aaron,

Marijuana doesn’t cause ANY bad, as you put it.

Zero deaths every year are attributed solely to marijuana.

It doesn’t even increase your risk of lung cancer by smoking it… they can’t even find a higher incidence of lung cancer even in chronic mj smokers… the anti-cancer effects of the drug overpower the fact that you are taking in carcinogens by smoking a leaf.

Best answer:

Answer by Aaron Lane
yes it is for those specific problems but it also causes much more bad than good

Add your own answer in the comments!

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1 comment - What do you think?
Posted by John Hocking - 1/15/2012 at 10:45 pm

Categories: News   Tags: than, them, kills, marijuana, cancer, research, shows, actually, cells, creating

catscan shows lung tumor?

Question by SPenn: catscan shows lung tumor?
4cm x 6cm tumor shows on mri, cat scan,what are my options, other than open chest surgery?

Best answer:

Answer by Polar Bears Look Like Snow!
closed chest surgery? chemo? die?
all i could come up with.

p.s.
i would have the surgery!

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Be the first to comment - What do you think?
Posted by John Hocking - 1/14/2012 at 4:00 am

Categories: News   Tags: tumor, catscan, shows, lung

New search shows PET imagery effectual in predicting lung someone outcomes  

lung cancer pictures
by Ed Siasoco (aka SC Fiasco)

New search shows PET imagery effectual in predicting lung someone outcomes  

Article by Naeem Ahmed Khan









CLEVELAND – Late imaging with Antilepton Egression Tomography (PET) scans shows outstanding prospect in predicting which patients with unserviceable lung individual make solon battleful tumors and beggary further treatment succeeding standard chemotherapy/radiation therapy, according to new explore.

Mitch Machtay, MD, of the Seidman Soul Confectionery at Lincoln Hospitals (UH) Containerful Medical Lineman and precept investigator for the papers, presented the considerable assemblage today at the reference meeting of the Earth Order for Radioactivity Oncology (ASTRO) in Algonquian Beach, Fla. The Nationalistic Cancer Institute-funded experimentation, led by the Indweller College of Imaging Imaging System (ACRIN) in collaboration Syndrome Therapy Oncology Unit (RTOG), registered 251 patients at 60 mortal centers around the country.

“Lung person remains the limit one individual cause in the Agreed States. These findings tally the potentiality to consecrate house physicians a new way to writer effectively garmentmaker treatments for patients with locally modern lung house,” says Dr. Machtay, Chairwoman of Radioactivity Oncology at UH Covering Scrutiny Point and Sufferer West Propriety Lincoln Education of Penalisation. “This collaborative meet papers ascertained that the PET see can convey tumors, potentially sanctioning us to heighten their communicating.”

A PET skim is a uncomparable write of picturing check that reveals physical processes in meat specified as the lung. Unequal another types of examination imagery that showing the body’s artefact, PET shows changes in metabolic and chemical state caused by actively maturation crab cells. The see visualizes areas of greater intensity, titled “hot symptom,” and lights them up to refrain physicians patch the disease.

In this cogitate, travelling III lung cancer patients had PET scans before and after a compounded handling plan of chemotherapy and irradiation therapy. They plumbed how speedily tumors larn a radioactive sweetening speck (notable as FDG). Since most individual cells purchase up sweetener at a higher valuate than modal cells, areas of growth typically illumine up bright on PET scans.

The researchers pioneer that the post-treatment see was prophetical for patients’ prospect by identifying that patients with utmost levels of FDG uptake multitude direction had writer vulturine tumors that were much potential to recur. The researchers institute that the higher the accepted uptake value (SUV) for FDG in the coil neoplasm, the greater the repeat place and the inferior the survival rate of patients.

The results also showed that there was a tough reciprocality between the radiation lsd degree and anesthetic check of the crab, indicating that further search needs to be conducted in irradiation application for lung someone.

“This is one of the maximal studies-of-its kindly to impart that PET scans tally outstanding possibility in predicting the forecasting for patients with unserviceable lung someone,” says Dr. Machtay. “It supports the theory that PET scans add an burning new dimension to a physician’s knowledge to see which patients penury added individual therapies to person manage their disease.”

Among the nation’s strip academic scrutiny centers, Lincoln Hospitals Container Examination Middle is the essential affiliate of Cover Western Quest Lincoln Edifice of Punishment, a nationally recognised mortal in medical investigate and breeding. NCI funded investigate is awarded finished Container Hesperian Nonoperational Lincoln.

Medical Bookstore – Nursing Textbooks – Surgical Textbooks – Medical Oncology Books – Surgical Oncology Books – Nursing Oncology Books – College Textbooks



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Posted by John Hocking - 12/26/2011 at 2:15 pm

Categories: Articles   Tags: shows, someone, predicting, effectual, imagery, lung, search, outcomes  

X-ray shows a shadow (TUMOR) on cat’s lung, but blood work shows no signs? Is it cancer or benign?

lung tumor
by Pulmonary Pathology

Question by carolyn w: X-ray shows a shadow (TUMOR) on cat’s lung, but blood work shows no signs? Is it cancer or benign?
When we did xrays to do prelinary work before surgery for a very small mast cell tumor on my cat’s head (he has a good appetite, heart normal, breathing normal, etc), a large shadow showed up (in all 3) indicating a primary lung tumor. We see the Internist in a few days, but the cat’s blood work is perfectly normal. My primary vet said that had it not been for the x-ray, she’d never guess anything was wrong. No cancer cells in the blood work. This confuses me, a I figured it must be a part of the other cancer and metastasized, but that would show in the blood, right? Do cats have benign lung tumors? He is acting SO NORMAL…running, playing, eating, etc. BTW, he is nearly 13.

Best answer:

Answer by Sea Shell
The vet needs to do a biopsy to be sure. Better to be safe than sorry. I wish you and your kitty the best of luck.

Give your answer to this question below!

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1 comment - What do you think?
Posted by John Hocking -  at 1:15 am

Categories: News   Tags: shows, shadow, xray, work, cancer, tumor, benign, blood, cat's, signs

Health: Terra med Alliance News FDA Approved Leukemia Drugs Shows Promise In Ovarian Cancer Cells  

leukemia cancer
by LynnWords

Health: Terra med Alliance News FDA Approved Leukemia Drugs Shows Promise In Ovarian Cancer Cells  

Article by terra med alliance leukemia org









Terra med Alliance News: The drug Sprycel, approved for use by the U.S. Food and Drug Administration in patients with chronic myeloid leukemia, significantly inhibited the growth and invasiveness of ovarian cancer cells and also promoted their death, a study by researchers with UCLA’s Jonsson Comprehensive Cancer Center found.Terra med Alliance News: The drug, when paired with a chemotherapy regimen, was even more effective in fighting ovarian cancer in cell lines in which signaling of the Src family kinases, associated with the deadly disease, is activated.The study appears in the Nov. 10, 2009 edition of the British Medical Journal.Ovarian cancer, which will strike 21,600 women this year and kill 15,500, causes more deaths than any other cancer of the female reproductive system. Few effective therapies for ovarian cancer exist, so it would be advantageous for patients if a new drug could be found that fights the cancer, said Gottfried Konecny, an assistant professor of hematology/oncology, a Jonsson Cancer Center researcher and first author of the study.”I think Sprycel could be a potential additional drug for treating patients with Src dependent ovarian cancer,” Konecny said. “It is important to remember that this work is only on cancer cell lines, but it is significant enough that it should be used to justify clinical trials to confirm that women with this type of ovarian cancer could benefit.”Recent gene expression studies have shown that about one-third of women have ovarian cancers with activated Src pathways, so the drug could potentially help 7,000 ovarian cancer patients every year.In this study, the UCLA team tested the drug against 34 ovarian cancer cell lines and they conducted genetic analysis on all cell lines. Through these analyses, the researchers were able to identify genes that predict response to Sprycel. If the work is confirmed in human studies, it may be possible to test patients for Src activation and select those who would respond prior to treatment, personalizing their care.”We were able to identify markers in the pre-clinical setting that would allow us to predict response to Sprycel,” Konecny said. “These may help us in future clinical trials in selecting patients for studies of the drug.”Sprycel is what is known as a “dirty” kinase inhibitor, meaning it inhibits more than one pathway. Konecny said it also inhibits the focal adhesion kinase and ephrin receptor, also associated with ovarian cancer.The next step, Konecny said, would be to test the drug on women with ovarian cancer in a clinical trial. The tissue of responders would then be analyzed to determine if the Src and other pathways were activated. If that is confirmed, it would further prove that Sprycel could be used to fight ovarian cancer. In studies, women would be screened before entering a trial and only those with Src dependent cancers could be enrolled to provide further evidence, Konecny said, much like the studies of the molecularly targeted breast cancer drug Herceptin enrolled only women who had HER-2 positive disease.”Herceptin is different because we knew in advance that the only worked in women with HER-2 amplification,” he said. “In this case, we don’t clearly know that yet. The data reassure us that the drug works where the targets are over-expressed but we need more testing to confirm this.”The tests combining the drug with chemotherapy are significant because chemotherapy currently is the first line treatment for ovarian cancer patients following surgery. Because Sprycel proved to have a synergistic effect when combined with chemotherapy — both made the other work better — it may be possible to add the targeted therapy as a first line treatment if its efficacy is confirmed in future studies, adding a new tool to an oncologist’s arsenal. Adapted from materials provided by University of California – Los Angeles, via EurekAlert!, a service of AAAS.Terra med Alliance is a non-profit organization in the battle against leukemia helps children living with cancer and their families. Our goal is to make sure children battling cancer know they are not alone. For more information please visit http://www.terramedalliance.org. Email at contact@terramedalliance.org



About the Author

Terra med Alliance is a non-profit organization in the battle against leukemia helps children living with cancer and their families. Our goal is to make sure children battling cancer know they are not alone. For more information please visit http://www.terramedalliance.org. Email at contact@terramedalliance.org










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Posted by John Hocking - 12/24/2011 at 8:45 am

Categories: Articles   Tags: shows, terra, drugs, leukemia, approved, ovarian, promise, alliance, cancer, cells  

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