Posts tagged "Therapies"

01-2 – Dominik Mumberg – The road to targeted therapies (Part 2)

1 Important Signal Transduction Pathways 2 Overview 3 FDA Approvals of Anti-Cancer Agents 4 HER Receptor Family 5 EGFR targeting antibodies and kinase inhibitors 6 Treatment-relevant mutations of EGFR in NSCLC 7 Approved Drugs against HER1 and HER2 8 Mechanisms of resistance to EGFR inhibitors 9 Targets synergistic to HER receptors 10 Drug candidates to PI3K, mTOR and MAPK 11 HIF-mediated signal transduction 12 Mitotic regulators as cancer targets 13 Conclusions — Targeted drugs 14 Do we simply need better cancer drugs? 15 Targeted application — definition 16 PI3-Kinase dependent signal pathways 17 Small molecule targeted drugs — context 18 Targeted antibodies — context 19 Conclusions — Targeted Applications
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Interrogating Circulating Tumor Cells to Direct Targeted Cancer Therapies

Air date: Wednesday, May 26, 2010, 3:00:00 PM Timedisplayed is Eastern Time, Washington DC Local Category: Wednesday Afternoon Lectures Description: Dr. Haber will present the development and characterization of a microfluidic device for the efficient capture of circulating tumor cells (CTCs) from blood specimens of patients with cancer. These cells represent potential biomarkers with which to follow disease progression, as well as providing important biological information into the process of metastasis. Examples will be provided, including the monitoring of tumor genotypes in EGFR-mutant lung cancer, as well as the molecular characterization of CTCs from patients with localized and metastastic prostate cancer. His laboratory interests have focused on the area of cancer genetics, including the etiology of the pediatric kidney cancer Wilms tumor and genetic predisposition to breast cancer. Recently, his laboratory reported that lung cancers with activating mutations in the epidermal growth factor receptor (EGFR) are uniquely sensitive to tyrosine kinase inhibitors that target this receptor. This observation has had important implications for the genotype-directed treatment of non-small cell lung cancer, and more broadly for strategies to identify critical genetic lesions in cancers that may serve as an “Achilles heel” and be suitable for molecular targeting. In collaboration with Dr. Mehmet Toner’s laboratory, Dr. Haber’s laboratory has recently established the …

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Haverhill MA Fibromyalgia Doctor- How Dr. Wheelwright treats Fibromyalgia with Nautral Therapies

Seacoast Functional Medicine is Boston’s premier natural alternative functional medicine practitioner, serving Massachusetts, New Hampshire, and the New England area. Seacoast Functional Medicine treats patients suffering from fibromyalgia, Type II Diabetes, Thyroid, Digestive Disorders, Respiratory Diseases, and many other chronic diseases. Contact Dr. Troy or visit the office in Haverhill, MA! www.seacoastfunctionalmedicine.com Call Dr. Troy 978-521-2225 Email twheelwrig@aol.com

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Alternative Therapies – Reflexology 1 of 6 – BBC Health Documentary Series

Alternative Therapies – Reflexology 1 of 6 – BBC Health Documentary Series Alternative Therapies Join Kathy Sykes on a personal journey of exploration into the controversial world of alternative therapies. Are there lessons for mainstream medicine to be learned from these increasingly popular therapies? Reflexologists claim that rubbing the soles of your feet can help you with medical conditions ranging from back pain to infertility. And it’s becoming big business. There are now some 30000 reflexologists in Britain working on about one million feet a year. In this programme, Kathy Sykes explores reflexology. She finds out about its basic idea: that the entire body is mapped onto the sole of the foot. Reflexologists claim that by using this map it is possible to detect problems in particular parts of the body and by pressing specific areas of the foot they can improve the health of those parts, including organs such as the lungs, the liver and the kidneys. Kathy’s journey starts with a surprise. Despite the often widely held view that reflexology’s origins lie deep in ancient Egyptian or Chinese medicine, it really began in upstate New York in the 1930s. Kathy then travels to Florida to meet the nephew of the woman who first coined the term reflexology. She also finds out about a reflexologist in Sheffield who believes that she has used the discipline to help bring over 100 babies into the world. But Kathy also meets mainstream scientists who are troubled by reflexology …

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Cancer-Free — Cancer Therapies That Work

beating-cancer-gently.plus101.com Cancer-Free — Cancer Therapies That Work. Join the thousands of people who have read my book and are free of cancer today as a result. I’ve explored the cause of their breast cancer, prostate cancer, lung cancer, colon cancer, brain cancer, etc. with them. Together we can always determine the cause. Has your cancer doctor discussed the cause with you? Why not? Once we’ve agreed on a cause Cancer-Free, Cancer, Therapies, That, Work, alternative cancer treatments, alternative cancer therapy, breast cance, colon cancer, cancer symptoms,symptoms of cancer r
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IS CANCER CURABLE ALTERNATIVE THERAPIES PART-5

Is Cancer Curable? Yes Siddha Yoga is the Answer Says Guru Siyag. FREE TREATMENT REMEDY CURE OPTIONS FOR CURING BLOOD CANCER BREAST CANCER TUMOUR LUNG CANCER THROAT CANCER AIDS/HIV SKIN CANCER BY GURU SIYAG’S SIDDHA YOGA. WE CAN ALSO TRY THIS ALTERNATIVE THERAPY AS A REMEDY CURE OR FOR PROTECTION FROM SWINE FLU DISEASE, AS IT IS FREE OF COST WITHOUT MEDICINE, WITHOUT ANYTHING TO GIVE OR TAKE. SINCE IT IS A DO IT YOURSELF METHOD AT HOME, THERE SEEMS NO HARM IN TRYING GURU SIYAG’S SIDDHA YOGA FOR SAVING THE MANKIND FROM DEADLY DISEASES.. This destructive process can be reversed by adopting the time tested Siddha Yoga, absolutely free of cost, said Guru Siyag, addressing a mass, at the Shaktipaat Diksha, initiation programme of Siddha Yoga, on 28th May, Thursday evening at Jodhpur, Rajasthan, India. If this method of Guru Siyags Siddha Yoga, based on the solid principles of Vedic Science is adopted, nobody can stop Mankind to win over deadly diseases. To achieve this, we will have to differentiate between the artificial Yoga and the Siddha Yoga. The Yoga going on today is a kind of physical body exercise, and not the Siddha Yoga as described by Maharishi Patanjalis Yoga Sutras. Diseases that humans suffer are classified by modern medical science into two broad categories — physical and mental. These are treated with internal medicines and/or external medicines or therapeutic applications. Ancient Indian sages delved deep into the mysteries of life through meditation and …
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Combining Targeted Therapies to ER+ Metastatic Breast Cancer: The Addition of mTOR Inhibitor

Part 3 of 3 – St. Gallen 2011: Targeted Therapies in Breast Cancer – Piecing Together Ways to Improve Patient’s Outcomes – Dr. Thomas Bachelot St. Gallen March 2011- Satellite symposium. The approaches to, and options for, the management of breast cancer are continually evolving. This is part 3 of 3 – Dr. Thomas Bachelot discusses “Combining Targeted Therapies to ER+ MBC: The Addition of mTOR Inhibitor”.
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Are there any safe conventional therapies for cancer covered by anthem blue cross?

Question by : Are there any safe conventional therapies for cancer covered by anthem blue cross?
as opposed to chemotherapy, surgery, and standard radiation? I know that there has to be a safer cancer treatment out there unlike chemotherapy or surgery and standard radiation that is covered by my health insurance or an alternative treatment for cancer. Any suggestions? oh, and one other thing… if you could find treatment centers on california’s central coast that would be awesome!! Thanks in advance!

Best answer:

Answer by Karen
You should contact the American Cancer Society. They have a full support system.

Give your answer to this question below!

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Latest drug therapies available for lung cancer?

Question by Bio: Latest drug therapies available for lung cancer?

Best answer:

Answer by DNA
Drugs worsen cancer cases because they are actually the best food for cancer cells.

Instead, I recommend systemic enzyme therapy that could boost your lungs so it can regenerate normal lung cells. Let your own immune system kill those cancer cells in your lungs.

Add your own answer in the comments!

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Making Sense of Alternative Cancer Therapies 1

Ruth Sackman talks about the differences between various alternative cancer therapies. This is vital information for anyone trying to understand the many different types of alternative cancer therapies, as well as conventional cancer therapies. Part 1.

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Making Sense of Alternative Cancer Therapies 4-Q&A

Ruth Sackman talks about the differences between various alternative cancer therapies. This is vital information for anyone trying to understand the many different types of alternative cancer therapies, as well as conventional cancer therapies. Part 4.
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Complementary vs. Alternative Cancer Therapies — Sloan-Kettering

Complementary therapies can ease cancer symptoms and side effects, while alternative therapies promise cures but are often invasive, harmful, and costly. Memorial Sloan-Kettering Cancer Center integrative medicine specialist Dr. Kathleen Wesa defines these treatment approaches, outlines how complementary medicine can benefit patients, and explains how to identify and avoid alternative therapies. For more information, please visit www.mskcc.org
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Cantonese Part 17 – Complementary & Alternative Therapies – Living with Lung Cancer

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Met Inhibitors: Targeted therapies for multiple cancers  

by Joost J. Bakker IJmuiden

Met Inhibitors: Targeted therapies for multiple cancers  

Article by Katewinslet

INTRODUCTION

Mesenchymal-epithelial transition (Met) tyrosine kinase is the receptor for hepatocyte growth factor (HGF), which is normally active in wound healing, liver regeneration, and embryonic development. However, the Met pathway is one of the most frequently dysregulated pathways in human cancer. Met dysregulation leads to constitutive activation of its tyrosine kinase activity thus increasing the downstream signals that lead to cell survival, proliferation, and migration. Patients with upregulated Met tend to have aggressive, chemo-resistant cancers and poor prognoses. For these reasons, the pharmaceutical industry has expended much time and effort to identify potential Met tyrosine kinase inhibitors as potential therapeutics for these cancers.

POTENTIAL THERAPEUTICS

CrizotinibThe drug Crizotinib has been discussed previously in its role as an EML4-ALK inhibitor for treating non-small cell lung carcinoma. However, Crizotinib is also a Met-inhibitor and shows promise in several other forms of histological cancer associated with Met-dysregulation.

ForetinibForetinib is an inhibitor of both Met and vascular endothelial growth factor receptor (VEGFR). Foretinib completed Phase I clinical trials in 2010 and showed potential in treating aggressive solid tumors. Phase II clinical trials are currently underway testing its efficacy in both lung and breast cancer.

CabozantinibLike foretinib, Cabozantinib inhibits both Met and VEGFR. It was granted orphan drug status by the FDA in 2011. The orphan drug status is available to encourage pharmaceutical companies to develop drugs for diseases, known as orphan diseases, which have a small market because they are relatively rare. Orphan drugs proceed through their development along the same regulatory pathways as other drugs with the exception that some statistical burdens may be lessened in recognition of the limited patient pool. Furthermore, other financial incentives are also linked to orphan drugs such as tax incentives and extended patent protection. These exceptions are in place to encourage the pharmaceutical industry to develop drugs for these rare diseases, which, by definition, would have a small market share and be relatively unprofitable.

Cabozanitib is currently in clinical trials for treatment of prostate, ovarian, brain, melanoma, breast, non-small cell lung, hepatocellular, kidney, and medullary thyroid cancer.

SUMMARY

The Met tyrosine kinase is one of the most dysregulated pathways in many cancers. The use of c-Met inhibitors with other therapeutic agents could be crucial for overcoming potential resistance as well as for improving overall clinical benefit in multiple types of cancer. Therefore, for more than two decades, investigators have been exploring Met inhibitors as potential cancer treatments. Three drugs currently in development are crizotinib, foretinib, and cabozantinib, all of which are currently in early phase clinical trials for treatment of several different cancers. Met inhibitors may prove to be a targeted type therapy with reduced toxicity, that are effective at halting metastasis and improving prognosis in many types of previously resistant tumors.

REFERENCES

1. Porter, J (February 2010), “Small molecule c-Met kinase inhibitors: a review of recent patents”, Expert opinion on therapeutic patents 20 (2): 159-177,2. Christensen JG, Schreck R, Burrows J, Kuruganti P, Chan E, Le P, Chen J, Wang XY, Ruslim L, Blake R, Lipson KE, Ramphal J, Do S, Cui JRJ, Cherrington JM, Mendel DB (November 2003), “A selective small molecule inhibitor of c-Met kinase inhibits c-Met dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo”, Cancer Research 63 (21): 7345-55,3. Underiner TL, Herbertz T, Miknyoczki SJ (January 2010), “Discovery of Small Molecule c-Met Inhibitors: Evolution and Profiles of Clinical Candidates”, Anti-cancer Agents in Medicinal Chemistry 10 (1): 7-27,4. Sattler M, Salgia R (April 2009), “The Met axis as a therapeutic target”, Update on Cancer Therapeutics 3 (3): 109-118,5. Christensen JG, Burrows J, Salgia R. (July 2005), “c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention”, Cancer Letters 225 (1): 1-26,6. Qian, F; Engst, S; Yamaguchi, K; Yu, P; Won, KA; Mock, L; Lou, T; Tan, J et al. (2009). “Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases”. Cancer research 69 (20): 8009-16.7. Illingworth, Patricia; Cohen, Jillian (2004). “Orphan Drug Policies: Implications for the United States, Canada, and Developing Countries”. Health Law Journal 12: 183.

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We pays great attention to the purity, stability and activity of the products like Compound Libraries, compound library, High Throughput Screening, Screening Libraries, Screening Library & more. Not only could we provides the chemical test data, such as HNMR, LC-MS and HPLC, but also provides the reviews overall evaluations of the products from the customers who have used our products. Western Blot, MTT, RT-PCR, ICH photos or figures provide a double guarantee for the biological activities of our products in life-science research.

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Chapter 17 Complementary Therapies: Lung Cancer, Understanding, Managing, Living

Thisfilm looks at what happens when a person is diagnosed with lung cancer through to available treatments and living with cancer. It provides expert medical information from a team of health professionals involved in caring for people with lung cancer, as well as experiences from people living with lung cancer. If you or someone you love has lung cancer this DVD may help you understand and make sense of what is happening, and what others have experienced.
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Aubrey de Grey – Progress in Therapies for Rejuvination and their Delivery – 2011-10-03

Aubrey de Grey speaks about different types of Ruminative Therapy Delivery. Sometimes there are some video delays because of bandwidth lag, but most information is there. Some parts of the research being deprioritized within SENS because research is going on elsewhere, such as some types Amyloid (extra cellular garbage), but SENS are working on the shrinkage of cells, Thyamis?… 04:33 Future of Monitoring the Body – motivation for monitoring people may be less if we assume the worse case scenario for everyone, and apply the therapies needed. 06:05 Transplantation: Issues of Rejection and Infection – Tissue Engineering is creating organs that have never been in another body, therefore risk of infection can be greatly minimised, and the organs can be created using the cells of the receivers body. The going has been slow, because of vascularisation (issues with getting blood flow), though change over past few years, we have been experimenting: take an organ, get rid of cells, but not the vasculature (veins), and take cells from the recievers body, and fill out the organ with his/her own cells leaving the vascelature in place. Mechanical or non-biological solutions – in some cases are looking very promising (ie Cochlear Implants – getting better very fast, could be 5 years away from them getting better than normal hearing). This will become more important as time goes on. Another way of avoiding the ionfection / rejection issues. Organs could come from another animal. 11:55 …
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Dr. Francisco Contreras – Part 2 – Alternative Cancer Therapies

Dr. Francisco Contreras, Oasis of Hope Hospital, formerly Contreras Hospital, comments on Alternative Cancer therapies vs. traditional medicine. Phone (888)500-HOPE Tijuana, Mexico
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IS CANCER CURABLE ? YES CANCER IS CURABLE BY ALTERNATIVE THERAPIES FREE OF COST

IS CANCER CURABLE ? IS BLOOD CANCER CURABLE ? IS BREAST CANCER CURABLE ? IS LUNG CANCER CURABLE ? IS THROAT CANCER CURABLE ? IS SKIN CANCER CURABLE ? IS CANCER TUMOUR CURABLE ? YES, GURU SIYAG’S SIDDHA YOGA BASED ON SOLID PRINCIPLES OF ANCIENT INDIAN VEDIC AND YOGA PHILOSOPHY IS THE ANSWER. MOST ECONOMICAL TREATMENT OPTIONS IN THE WORLD, GURU SIYAG SIDDHA YOGA ALTERNATIVE THERAPY, REMEDY, CURE FOR DISEASES LIKECANCER AND AIDS. CURING CANCER AND AIDS WITHOUT MEDICINE BY GURU SIYAG’S SIDDHA YOGA ALTERNATIVE THERAPY HOLISTIC HEALING TO CURE BLOOD CANCER, BREAST CANCER, SKIN CANCER, OTHER CANCER TUMOURS, AIDS MENTAL DISORDERS, MENTAL ILLNESS, INSOMNIA AND OTHER PHYSICAL MENTAL AND SPIRITUAL DISEASES FREE OF COST FOR EVERY HUMAN BEING. WE CAN TRY THIS ALTERNATIVE THERAPY AS A REMEDY CURE OR PROTECTION FROM SWINE FLU DISEASE, AS IT IS FREE OF COST WITHOUT MEDICINE, WITHOUT ANYTHING TO GIVE OR TAKE THERE APPEARS NO HARM IN TRYING IT. SINCE IT IS A DO IT YOURSELF METHOD AT HOME, THERE SEEMS NO HARM IN TRYING GURU SIYAG’S SIDDHA YOGA FOR SAVING THE MANKIND FROM SWINE FLU, CANCER OR AIDS. Any person with a positive approach can himself experience and verify the truth about the potential powers of Spiritual Science by Guru Siyag’s Siddha yoga. One can experiment it practically by following a simple 15 minutes, free of cost, Do it yourself “Method of Meditation” Free Download and more info on www.the-comforter.org avskworld@gmail.com
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Find Alternative Cancer Therapies Through The Cancer Control Society

www.thenaturalguide.com – Cancer Treatment Why poison the body with chemotherapy and radiation when the body can fight cancer on its own, and beat it!? It just needs the right nutritional supplements and other highly effective nontoxic natural therapies to do the job. But who does that? And what is the therapy, you ask? Turn to the Cancer Control Society for lists of qualified doctors and therapies in your area. The Cancer Control Society has been promoting alternative therapies and helping connect people with experts for 40 years. In this video, Lorraine Rosenthal, co-founder of the Cancer Control Society, gives us an overview of what you can find at their website, booths (they go to 20 fairs per year) and their very own yearly cancer convention. I talk about cancer and the alternative therapy cover-up on my website at: www.thenaturalguide.com Interviewee Lorraine Rosenthal www.cancercontrolsociety.com Video Producer Larry Cook http

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Alternative Therapies for Cancer: Successful Studies Using Essential Oils  

by ToastyKen

Alternative Therapies for Cancer: Successful Studies Using Essential Oils  

Article by Eric Cech

In the last several years, as researchers expand their search for novel anticancer plants and compounds, certain essential oils have been repeatedly turning up in published reports as being potential future therapies for cancer treatment. Essential oils are particular kinds of extracts from plants — they are what give plants their aromas. More alcohol-like than oil-like, these compounds easily evaporate and are readily detected by our olfactory systems. Less known is that these volatile compounds are often highly complex, and can be very unique from plant to plant. A great many of these oils have been the subject of medical research in several fields, and are noted for their anti-viral, anti-bacterial, and inflammation-reducing actions. Now, their anticancer activities are coming to light as well.

Two Outstanding Essential Oils Researched for Anticancer Activity

The essential oils distilled from Frankincense resin and from the leaves of Lemongrass have been the subject of more scientific inquiry regarding their efficacy as cancer treatments than any other oils. Why this is so is somewhat uncertain, though both these plants have a long history of use as medicines. The term Frankincense refers specifically to the resin or sap of one of several species of Olibanum tree, native to east Africa and India. The resin even has biblical significance, being one of the gifts of the Magi to the newly-born Jesus — it was at that time a very costly medicine, incense and perfume. Lemongrass has been used in more tropical environs for its anti-infectious properties, with detoxifying effects several bodily systems. It is said to aid in digestion, circulation, and in clearing the skin.

Modern Research Proves Ancient Medicine’s Potential

Frankincense essential oil is noted in “The Complete Guide to Aromatherapy” by Salvatore Battaglia as an immuno-stimulant, an oil that does not eradicate viruses or bacteria directly, but improves the body’s own natural immunity. A look at the research performed over the last few years is quite impressive: several pages of abstracts are returned when searching specifically for research regarding its potential as a cancer therapy. Many of these investigations have found the same result: Frankincense (and actually other essential oils that have similar effects) apparently targets only cancerous cells, leaving otherwise healthy cells unaffected.

Research is focusing on the chemical components of the essential oil unique to frankincense: the Boswellic acids. These natural compounds have been thoroughly studied for their anti-inflammatory activity, with a significant body of positive results. Boswellic acids can be used to reduce pain and inflammation in arthritic joints, and has even been shown to improve the texture and appearance of skin that may be prematurely aged due to sun overexposure. It is these same Boswellic acids that have been shown to induce natural cell death in cancerous cells — it is one of the features of cancer that natural cell death does not occur, and the cancerous cells then in essence grow unabated throughout the body.

Impressive Targeting of Cancer Cells

The conclusion of a study published in the journal of Complementary and Alternative Medicine, March 2009, by researchers at the University of Oklahoma was “Frankincense oil appears to distinguish cancerous from normal bladder cells, and suppress cancer cell viability”. This is truly a profound result, when considering what modern chemotherapy does — reduces the viability of all cells in and surrounding a tumor, with the hope that healthy cells live through the process in significant enough numbers that the patient recovers. Similar results have been published for a great many kinds of cancer: melanoma, leukemia, liver, colon and prostate, and anecdotal reports have supported its use in the treatment of breast cancer as well.

Lemongrass: Tropical Healer

The first result of a search for ‘lemongrass’ and ‘cancer’ is a paper titled “Anticancer activity of an essential oil from Cymbopogon flexuosus” (Cf is a popular species of Lemongrass, though other research also shows similar effects from Cymbopogon citratus). This study published in the May 2009 ‘Chemico-biological Interactions’, performed at the Indian Institute of Integrative Medicine, examined both in-vitro (essentially “in the test tube”)and in-vivo (in the body) anticancer activity of Lemongrass essential oil. The oil was actually evaluated for efficacy against 12 cancer cell lines in-vitro, and 2 in-vivo. The results were no less than astounding. Lemongrass was effective at inhibiting proliferation of all the cell lines, though with significant variation in the concentrations required for this effect. The lowest concentrations of Lemongrass were needed to inhibit growth of colon cancer and neuroblastoma cells in-vitro (a type of cancer of the nerve cells occurring in children and infants). Using mouse models, lemongrass essential oil was effective at limiting proliferation of a type of breast cancer and a connective-tissue cancer.

Israeli researchers, publishing their results in the May 2007 Planta Medica, discovered similar results focusing on a primary constituent of Lemongrass essential oil: Citral. This natural constituent adds the ‘lemony’ aroma to many essential oils, including of course Lemon, Melissa, and Lemon Verbena. Citral was noted to also show cancer cell specificity (liver cancer cells were evaluated in this case), causing only the cancer cells to die off. It appears that lemongrass essential oil, like Frankincense, also induces natural cell death in cancer cells, sparing normal healthy cells in the process.

These studies (and others available through medical research databases) are indeed promising — most noting in some way that the low toxicity, availability and cancer-cell specificity of these natural compounds warrant further investigation. Because of the current climate regarding funding of alternative therapies, it will take either a government wishing to significantly save on health care costs, or a large grass roots effort, to further the research to a point where specific therapeutic protocols are developed. In the meantime, there are many respected, well-educated health professionals that may be willing to offer advice for those wishing to learn more on how Frankincense and/or Lemongrass might be employed as preventative measures. Please note, this articles is not meant to offer medical advice, but simply to report recent updates in medical research. It is not a substitute for sound professional medical advice from your physician or other qualified healthcare provider.

About the Author

The author has a significant body of experience involving the the therapeutic use of essential oils, and is an advocate of using natural means for healing whenever they offer the most effective choice. For more in-depth reading, visit The Ananda Apothecary at www.anandaapothecary.com, and to find professional quality aromatherapy supplies, visit www.synergyessentialiols.com.

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